Article Correctness Is Author's Responsibility: Hormones in the Brain May Explain How Exercise Improves Metabolism February 2, 2021 Author: Neuroscience News Category: brain researchThe article below may contain offensive and/or incorrect content. Exercise promotes the hypothalamus to release MOTS-c. Mitochondrial encoded MOTS-c interacts with the nuclear genome and regulates both cell metabolism and the stress response.